Last edited by Kezshura
Sunday, April 26, 2020 | History

3 edition of Targeting the Wnt pathway in cancer found in the catalog.

Targeting the Wnt pathway in cancer

Kathleen Heppner Goss

Targeting the Wnt pathway in cancer

  • 311 Want to read
  • 27 Currently reading

Published by Springer in New York .
Written in English

    Subjects:
  • Neoplasms,
  • Genetics,
  • Methods,
  • Wnt Proteins,
  • Therapy,
  • Signal Transduction,
  • Targeted Gene Repair

  • Edition Notes

    Includes bibliographical references and index.

    StatementKathleen H. Goss, Michael Kahn, editors
    Classifications
    LC ClassificationsRC271.G45 T37 2011
    The Physical Object
    Paginationxi, 240 p. :
    Number of Pages240
    ID Numbers
    Open LibraryOL25021819M
    ISBN 101441980229, 1441980237
    ISBN 109781441980229, 9781441980236
    LC Control Number2011920692
    OCLC/WorldCa720560332


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Targeting the Wnt pathway in cancer by Kathleen Heppner Goss Download PDF EPUB FB2

Almost two decades of study has confirmed that Wnt signaling is necessary and sufficient for cancer pathogenesis in multiple in vitro and in vivo models systems, suggesting that the pathway represents an attractive therapeutic target.

Recent efforts have focused on innovative strategies to antagonize Wnt signaling at various levels of the. Targeting the Wnt Pathway in Cancer by Kathleen H. Goss,available at Book Depository with free delivery worldwide. from book Targeting the Wnt Pathway in Cancer (pp) Targeting Wnt Signalling in Cancer.

Chapter January Chapter 5 looks at the Dysregulation of Wnt in many common cancers including prostate, pancreatic, breast and colon. The discussion provides an excellent summary for those wishing to put some of the pieces together on this protein.

Chapter 8 presents some detailed current efforts on targeting Wnt and this is exceptionally well done.5/5. WNT Pathway Dysregulation in Cancer. The importance of aberrant WNT signaling in tumorigenesis was first discovered during tumor induction in a mouse model following proviral insertion at the Targeting the Wnt pathway in cancer book locus [].Activated WNT signaling has also been implicated in proliferation, survival, and ability to metastasize in various cancers cell by:   Targeting the Wnt pathway in cancer is an attractive therapeutic approach.

However, success has been limited because of the lack of effective therapeutic agents and the lack of biomarkers to define the patient population that would benefit from such a therapy. Herein, we report the discovery of LGK, a drug that targets Porcupine, a Wnt Cited by:   Wnt signaling is an evolutionarily conserved pathway that controls cell-to-cell interactions during embryogenesis.

In adults, Wnt signaling plays a role in tissue homeostasis in almost every organ system. Aberrations within this pathway are implicated in a spectrum of human diseases. A variety of perturbations have been described in both solid and hematologic Cited by: In this study, we used a Wnt-responsive Super-TOPflash (STF) luciferase reporter assay to screen a new compound targeting Wnt signaling.

3-(5′-Hydroxymethyl-2′-furyl)benzylindazole (YC-1) was identified as a small molecule inhibitor of the Wnt/β-catenin pathway. Request PDF | Targeting the Wnt signaling pathway in colorectal cancer | Introduction: The treatment of patients with advanced colorectal cancer.

Accordingly, pharmacological blocking of Wnt signaling has been considered an attractive therapeutic approach for colorectal cancer. Several therapeutics targeting various molecular components of the Wnt signaling pathway, including porcupine, frizzled receptors and co-receptor, tankyrases, and cAMP response element binding protein (CREB Cited by: The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years.

This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and Brand: Springer New York. The Wnt signaling pathway is critically involved in both the development and homeostasis of tissues via regulation of their endogenous stem cells.

Aberrant Wnt signaling has been described as a key player in the initiation of and/or maintenance and development of many cancers, via affecting the behavior of Cancer Stem Cells (CSCs).Cited by: Get this from a library.

Targeting the Wnt pathway in cancer. [Kathleen Heppner Goss; Michael Kahn;] -- Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as. Targeting the Wnt Signaling Pathway to Treat Colon Cancer Approximatelypeople are diagnosed with colorectal cancer every year in the United States, and 1/3 of these die from the disease.

Treatment options currently include surgical resection if the tumor has not progressed to an advanced stage and. Targeting the Hedgehog pathway in cancer. Published by Guset User, Description: During embryonic development, the Hedgehog (Hh) signalling pathway regulates proliferation and differen-tiation in a time- and position-dependent fashion (for a.

Targeting the Wnt Pathway in Cancer Paul Polakis (auth.), Kathleen H. Goss, Michael Kahn (eds.) The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers.

Title:Targeting AMPK Signaling Pathway to Overcome Drug Resistance for Cancer Therapy VOLUME: 17 ISSUE: 8 Author(s):Zhiyu Wang, Pengxi Liu, Qianjun Chen, Shigui Deng, Xiaoyan Liu, Honglin Situ, Shaowen Zhong, Swei Hann and Yi Lin Affiliation:Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Cited by: This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and Targeting the Wnt Pathway in Cancer Free PDF d0wnl0ad, audio books, books to read, good books to read, cheap books, good books, online books, books online, book reviews epub, read books online, books to read.

University of Colorado Anschutz Medical Campus. (, June 4). Wnt stem cell signaling pathway implicated in colorectal cancer in patients under ScienceDaily.

Retrieved April 6, from www. Abstract. Background: The role of Wnt signalling in carcinogenesis suggests compounds targeting this pathway as potential anti-cancer drugs.

Several studies report activation of Wnt signalling in biliary tract cancer (BTC) thus rendering Wnt inhibitory drugs as potential candidates for targeted therapy of this highly chemoresistant disease.

Abstract: Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of many tumors, including breast cancer. In the normal breast, tightly regulated expression of Wnt/β-catenin pathway components, including Wnts and the APC tumor suppressor, dictates its role in balancing stem cell self-renewal, maintenance and differentiation during embryonic and postnatal.

apeutic targeting of Wnt/b-catenin signaling has received considerable interest in the context of cancer. Dysregulated Wnt/b-catenin signaling oc-curs inmanysolid tumorsand hematologic ma-lignancies even in the absence of documented mutations.

Frequently, altered levels of expres-sion of Wnt/b-catenin pathway regulators have. Despite being most often linked with colorectal cancer, WNT pathway activation has now been associated with virtually every type of solid cancer that occurs in humans, although the frequency can vary dramatically among tumor subtypes and specific pathway by: 8.

Wnt/β-Catenin Signaling Pathway as Novel Cancer Drug Targets Current Cancer Drug Targets,Vol. 4, No. 8 mutations in its downstream targets are frequent [33,]. The oncogenic role of β-catenin was highlighted by the discovery in which activating β-catenin mutations wereCited by: The Wnt/β-catenin pathway, which signals through the Frizzled (Fzd) receptor family and several coreceptors, has long been implicated in cancer.

Here we demonstrate a therapeutic approach to targeting the Wnt pathway with a monoclonal antibody, OMPR5. Targeting a specific pathway aberrantly upregulated in cancer cells has shown immense potential in cancer therapy. Although specific signaling pathways have been previously targeted for cancer therapy, the Wnt pathway has been rarely explored in this pursuit.

Also an important facet of cancer theranostics is cellular bio-imaging. Targeting Cancer Stem Cells with NonToxic Therapies by Jeffrey Dach MD When Jim was 36 year old, he was diagnosed with acute myeloblastic leukemia with symptoms of fatigue, anemia, and extremely high white count on his blood panel.

The first well-characterized Wnt pathway in C. elegans was a noncanonical pathway that mediates a signal from P2 to EMS required for endoderm formation (see below). In this pathway, the homologs of APC, GSK3 β and TCF behave in an opposite manner from similar proteins in other species, suggesting that Wnt signaling was fundamentally different in worms (Han, ).

Role of Wnt receptor LRP6 in breast cancer promotion and progression is well known. We hypothesized that interactions between cancer cells, macrophages, and endothelial cells induce cancer stemness via activation of Wnt/-β catenin pathway, and blocking that pathway will reduce primary and metastatic tumors.

Targeting the stem of cancer: Inhibition of the WNT pathway in colorectal tumours Date 10 September These mutations were associated with activation of the Wnt/b-catenin signaling pathway. We hypothesize that mutations in exon 3 of CTNNB1 reprogram the molecular landscape leading to clinically aggressive EEC.

Understanding of these mutations will better inform specific strategies targeting the Wnt pathway including cyclin D and CDK4. Acquired resistance to Tamoxifen remains a critical problem in breast cancer patient treatment, yet the underlying causes of resistance have not been fully elucidated.

Abberations in the Wnt signalling pathway have been linked to many human cancers, including breast cancer, and appear to be associated with more metastatic and aggressive types of by:   The Wnt, Notch and Hedgehog (HH) pathways are developmental pathways that are commonly activated in many types of cancer.

While substantial progress has been made in developing therapeutics targeting Notch and HH, the Wnt pathway has remained an elusive therapeutic target.

Dishevelled-independent WNT/ PCP signals are transduced to the NLK signaling cascade through MAP3K7 (TAK1). ANKRD6, NKD1 and NKD2 induce class switch from the WNT/GSK3β signaling pathway to the WNT/PCP signaling pathway.

WNT5A is up-regulated in various types of human cancer, such as gastric cancer, lung cancer, and melanoma. The important roles played by Wnt/β-catenin signaling in cancer prompted the development of targeted agents directed at different components of the Wnt/β-catenin pathway.

During the past decade, numerous Wnt/β-catenin inhibitors have been tested in preclinical models of different cancers, with some moving on to clinical trials [1, 4, 21].Cited by: 7.